The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life. However, almost nothing is known about how AC activity is regulated through protein degradation mediated by ubiquitination or other mechanisms. Here, we show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Se...

Adenylyl Cyclase Complex

Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.

Adenylyl cyclase (AC) isoforms 1 to 9 are differentially expressed in tissues and constitute an interesting drug target. ACs 1 to 8 are activated by the diterpene, forskolin (FS). It is unfortunate that there is a paucity of AC isoform-selective activators. To develop such compounds, an understanding of the structure/activity relationships of diterpenes is necessary. Therefore, we examined the ...

INTERACTS with MULTIPLE ADENYLYL CYCLASE ( AC ) ISOFORMS and SCAFFOLDS AC 5 and 6 to AMPA RECEPTORS

AKAP79 INTERACTS with MULTIPLE ADENYLYL CYCLASE (AC) ISOFORMS and SCAFFOLDS AC 5 and 6 to AMPA RECEPTORS Riad Efendiev, Bret K. Samelson, Bao T. Nguyen, Prasad V. Phatarpekar, Faiza Baameur, John D. Scott, and Carmen W. Dessauer* From the Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, Texas 77030 and the Howard ...

Lithium preferentially inhibits adenylyl cyclase V and VII isoforms.

Lithium ions' inhibition of adenylyl cyclase (AC) has not been previously studied for the newly discovered AC isoforms. COS7 cells were transfected with each of the nine membrane-bound AC isoforms cDNAs with or without D1- or D2-dopamine receptor cDNA. AC activity was measured as [3H]cAMP accumulation in cells pre-incubated with [3H]adenine followed by incubation with phosphodiesterase inhibito...